As a couple, Brancacci Chapel (Santa Maria del Carmine) works.
Masaccio's Expulsion from Eden and Tribute Money here are where Renaissance painting effectively begins — a pilgrimage for anyone who cares about art history, freshly restored and seen up close from a viewing platform. The catch: entry is timed to small groups and must be booked, it's a single room across the river, and the significance is lost on casual visitors. A specialist's WORTH_IT, a generalist's skip.